Transforming Growth Factor-Alpha in the Adult Bovine Ovary: Identification in Growing Ovarian Follicles1
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چکیده
منابع مشابه
Expression of transforming growth factor-alpha in the human ovary during follicular growth, regression and atresia.
The cytologic localization and cellular levels of TGF alpha in the human ovary during follicular growth and regression were examined by avidin/biotin immunoperoxidase techniques with a monoclonal antibody to TGF alpha. In primordial follicles, only the oocyte showed intense immunostaining for TGF alpha, whereas the flattened pregranulosa cells were negative for the immunostaining. The earliest ...
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The potential of transforming growth factor-alpha (TGF-alpha) to function as an autocrine growth factor was evaluated in numerous ovarian carcinoma cell lines. All 17 lines which were examined expressed the epidermal growth factor receptor and 16 cell lines, in addition, concomitantly secreted TGF-alpha. Radioimmunoassay of processed serum-free-conditioned medium indicated TGF-alpha concentrati...
متن کاملExpression and action of transforming growth factor alpha in normal ovarian surface epithelium and ovarian cancer.
Greater than 95% of ovarian cancers originate in the epithelial cells on the surface of the ovary. The current study investigates the expression and action of transforming growth factor alpha (TGFalpha) in ovarian surface epithelium (OSE) and the underlying stroma in both normal and tumorigenic ovarian tissues. Normal bovine ovaries are used in the current study as a model system to investigate...
متن کاملParental cigarette smoking, transforming growth factor-alpha gene variant and the risk of orofacial cleft in Iranian infants
Objective(s):We investigated the influence of genetic variation of the transforming growth-factor alpha (TGFA) locus on the relationship between smoking and oral clefts. Materials and methods:In this study 105 Iranian infants with non-syndromic cleft lip/palate and 218 controls with non-cleft birth defects were examined to test for associations among maternal exposures, genetic markers, and ora...
متن کاملTransforming Growth Factor Alpha in Normal and Abnormal Growth
.................................................................................... 5 ABBREVIATIONS .......................................................................... 7 FOREWORD ................................................................................... 9 INTRODUCTION .......................................................................... 10 GENERAL ASPECTS ON GROWTH REGULAT...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1989
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod40.5.1087